دانلود کتاب Soft Matter Systems for Biomedical Applications

Table of contents :
Preface
Contents
List of Contributors
Part I Fundamentals of Soft Matter Systems
1 Water Contribution to the Protein Folding and Its Relevance in Protein Design and Protein Aggregation
1.1 Introduction
1.2 Hawley’s Theory
1.3 The Model for the Hydrated Protein
1.3.1 The Franzese-Stanley Coarse-Grained Water Model
1.3.2 The Coarse-Grained Hydration Water Model
1.3.3 The Coarse-Grained Protein-Water Model
1.4 Protein Design
1.4.1 Design Protocols
1.4.2 Design Results in Two Dimensions
1.4.3 Design Results in Three Dimensions
1.5 Protein Unfolding as a Precursor of Protein Aggregation
1.6 Conclusions
References
2 Slow Dynamics of Biological Water
2.1 Introduction
2.2 Methods
2.3 Hydration Water
2.4 Slow Dynamics of Hydration Water Probed with Self Intermediate Scattering Functions
2.4.1 The α-relaxation of Hydration Water
2.4.2 The Long-Relaxation of Hydration Water and Its Connections to the Biomolecule Dynamics
2.5 Slow Dynamics of Hydration Water Probed with Self van Hove Correlation Functions
2.5.1 α-relaxation of Hydration Water and Cage-Escaping Hopping
2.5.2 Long-Relaxation of Hydration Water and Protein-Related Hopping
2.6 Conclusions
References
3 Molecular Perspective on Solutions and Liquid Mixtures from Modelling and Experiment
3.1 Introduction
3.2 Classical Molecular Simulations
3.2.1 Force Fields
3.3 Structure of Molecular Liquids and Liquid Mixtures
3.3.1 Radial Distribution Functions
3.3.2 Spatial Distribution Functions
3.3.3 Cluster Analysis and H-Bonded Structures
3.4 Physical Observables
3.4.1 Density
3.4.2 Excess Molar Volume of Mixing
3.4.3 Excess Molar Enthalpy of Mixing
3.4.4 Viscosity
3.4.5 Translational Diffusion
3.4.6 Structure Factors
3.5 Case Studies
3.5.1 Unusual Density Variation
3.5.2 Excess Molar Enthalpies and Volumes of Alcohol Ether Mixtures and Their Dependence on the Clustering
3.5.3 Is the [PtCl6]2− Ion Preferentially Solvated by the Organic Solvent in a Water + Organic Solvent Solution?
3.5.4 The Low-Q Excess
3.5.5 Hydration of DNA Counterions
3.5.6 Is It Worth Trying to Calculate Viscosity for Ionic Liquids from Computer Simulations When the Experiments Fail?
3.6 Conclusions
References
4 Lyotropic Liquid Crystal Phases of Phospholipids as Model Tools in Molecular Biophysics and Pharmacology
4.1 Introduction
4.2 General Properties of Phospholipid Membranes
4.2.1 Chemical Structure of Phospholipid Molecules
4.2.2 Phase Transitions of Phospholipid Membranes
4.3 Membranotropic Effects of Individual Drug Substances
4.3.1 Effects of Drug-Membrane Interactions
4.3.2 Molecular Aspects of Drug-Membrane Interactions
4.4 Membranotropic Effects of Drugs Combinations
4.4.1 Kosmotrope and Chaotrope Substances
4.4.2 Kinetics of Joint Drug-Membrane Interactions
4.5 Lipid Membranes Affected by External Factors: From Membranotropic Effects to Biomimetic Sensor Materials
4.5.1 Effects of Provitamin D Photo-Transformations on Thermodynamic Parameters of Model Lipid Membranes
4.5.2 Provitamin D Photo-Isomerisation in Cholesteric Liquid Crystals: Development of Sensor Materials for Bioequivalent Dosimetry of UV Radiation
4.6 Final Remarks and Perspectives
References
5 Colloidal Particles in Confined and Deformed Nematic Liquid Crystals: Electrostatic Analogy and Its Implications
5.1 Introduction
5.2 Elastic Interactions in Nematic Liquid Crystal Colloids
5.3 Multipole Coefficients and Particles Symmetry
5.3.1 Polar Anchoring
5.3.2 Azimuthal Anchoring and Chiral Colloids
5.4 Banana-Shaped Particles in a Nematic Cell
5.4.1 Homeotropic Cell
5.4.2 Planar Cell
5.5 Elastic Monopoles in a Nematic Cell
5.6 Colloidal Particles in a Deformed Nematic
5.7 Distribution of Nanoparticless in a Deformed Nematic
5.8 Coexistence of Two Colloidal Structures at the NLC-Air Interface
5.9 Conclusions
References
Part II Mechanisms and Molecular Interactions
6 DNA-Polyamine Interactions: Insight from Molecular Dynamics Simulations on the Sequence-Specific Binding of Spermidine3+
6.1 Introduction
6.2 Features of DNA-Counterion Interactions
6.3 Molecular Dynamics Simulations of DNA with Polyamines
6.4 Distribution of Spermidine3+ Around DNA
6.5 Sequence Specificity of DNA-Polyamine Binding
6.6 DNA-DNA Interactions
6.7 Discussion and Conclusions
References
7 The Influence of Sequence Dependence and External Solvents on DNA Conformation
7.1 Introduction
7.2 Methods
7.3 Influencing Factors of DNA Conformational Transition
7.3.1 Sequence Dependent-Induced DNA Conformational Transition
7.3.2 Distribution of Ions Around DNA
7.4 Configuration Transformation of DNA in Different Solvents
7.4.1 The Structural and Dynamic Properties of Alcohol Solvents
7.4.2 Alcohols Solvent and Low Activity Water Induced DNA Conformational Transitions
7.5 Conclusions
References
8 Mechanisms of Heteroassociation of Ceftriaxone and Doxorubicin Drugs with Bovine Serum Albumin
8.1 Introduction
8.2 Preparation of Samples and Experimental Methods
8.3 Results and Discussion for Doxorubicin
8.3.1 Quantum Chemical Modeling of the Electronic Structure of Doxorubicin Molecules
8.3.2 Interaction in DOX-BSA Conjugates
8.3.3 Excitation Energy Transfer in the BSA-DOX System
8.3.4 Molecular Docking Study of the BSA-DOX Conjugates
8.3.5 Parameters of the Interaction in BSA-DOX Conjugates
8.3.6 Mechanisms of Intermolecular Interaction in BSA-DOX Conjugates
8.3.7 Conformational Transformations of BSA Macromolecules in Their Interaction with DOX Molecules
8.4 Results and Discussion for Ceftriaxone
8.4.1 Absorption Spectrum of Ceftriaxone
8.4.2 Molecular Docking Study of the BSA-Cef Conjugates
8.4.3 Nonradiative Transfer of Excitation Energy in the BSA-Cef Molecular System
8.4.4 Parameters of Intermolecular Interaction in the BSA-Cef System
8.4.5 Mechanisms of Intermolecular Interaction in the Aqueous Solutions of BSA-Cef
8.5 Conclusions
References
9 Manifestation of Structural Isomerism in the Raman Spectra of Platinum Drugs
9.1 Introduction
9.2 Experimental Details
9.3 Structure and Vibrational Analysis
9.4 Symmetry, Prenormal Coordinates and Normal Vibrations of Cis- and Trans-Isomer Skeletons
9.5 Raman Spectra of Cisplatin and Transplatin
9.6 Conclusions
References
10 Approaches for a Closer Look at Problems of Liquid Membranes with Amyloid-Beta Peptides
10.1 Introduction
10.2 Membrane Phase Transitions
10.3 Overall Membrane Thickness
10.4 Detailed Membrane Structure
10.5 Single Planar Membrane
10.6 Membrane Dynamics
10.7 Aβ Peptide Secondary Structure
10.8 Concluding Remarks
References
11 Analysis of Natural and Engineered Amyloid Aggregates by Spectroscopic and Scattering Techniques
11.1 Introduction
11.2 Differences in the Origin of Natural Functional and Engineered Amyloids
11.3 Spectroscopic and Scattering Techniques for Fibril Analysis
11.3.1 Infrared Spectroscopy
11.3.2 Electron Paramagnetic Resonance Spectroscopy
11.3.3 Small Angle X-ray Scattering
11.4 Conclusion/Outlook
References
Part III Magnetic Field Effects
12 Liquid Biosystems in Gradient Magnetic Fields: Electrokinetic, Magnetophoretic and Orientation Effects
12.1 Magnetic Field Sources of Artificial and Biogenic Origin Acting on Biosystems
12.2 Magnetophoretic Effects in Liquid Biosystems
12.2.1 Magnetic Tweezers for Biomedical Applications
12.2.2 Phase Separation of Liquid Media Under Gradient Magnetic Fields
12.2.3 Magnetophoresis of the Internal Components of the Body. Biogenic Magnetic Nanoparticles as Magnetic Organelle
12.3 Electrokinetic Effects Under Gradient Magnetic Fields
12.4 Orientation Effects in Strong Magnetic Fields
12.5 Final Remarks and Future Perspectives
References
13 Magnetic Fluids in Biosciences, Biotechnology and Environmental Technology
13.1 Introduction
13.2 Bioapplications of Magnetic Fluids
13.2.1 Magnetic Modification of Diamagnetic Materials
13.2.2 Synthesis of Magnetically Responsive Biobased and Related Materials
13.2.3 Separation of Biologically Active Compounds
13.2.4 Ferrofluid Modified (Bio)sorbents for Pollutant Removal
13.2.5 (Bio)analysis Using Ferrofluids and Ferrofluid-Modified Materials
13.2.6 Immobilization of Biologically Active Compounds and Cells on Ferrofluid-Modified Carriers
13.2.7 Other Biotechnology Applications of Ferrofluid Modified Materials
13.2.8 Peroxidase-Like Activity of Ferrofluid-Derived Materials
13.3 Conclusions
References
Part IV Nanosystems and Nanomaterials for Biomedical Applications
14 Smart Polymer-Based Multicomponent Nanosystem for Enhanced Anticancer Photodynamic Therapy
14.1 Introduction
14.2 Polymer Nanocarrier
14.3 Nanosystems for PDT
14.4 Methods Used for Nanosystems Study
14.5 In Vitro Experiments with Malignant Cells
14.6 Results and Discussion
14.7 Conclusions
References
15 Biomedical Applications of Laponite®-Based Nanomaterials and Formulations
15.1 Introduction
15.2 Structure and Properties of Lap
15.2.1 Grades of Lap
15.2.2 Properties of Lap
15.2.3 Modified Lap
15.3 Drug Delivery Systems
15.3.1 Examples of Pharmaceutical Molecules
15.3.2 Nanoscale Drug Delivery Systems
15.4 Medical Lap-Based Hydrogels
15.4.1 Types and General Properties of Hydrogels
15.4.2 Gradient Hydrogels
15.4.3 Stimuli-Responsive Hydrogels
15.4.4 Medical Applications of Lap-Based Hydrogels
15.5 Cytotoxicity and Antimicrobial Activity Assessments
15.5.1 Toxicity Tests
15.5.2 Antimicrobial Tests
15.5.3 Examples of Bioactivity Assessments
15.6 Final Remarks and Perspectives